2 hundred and you will eighty-half a dozen instances of NF1 and lady cancer of the breast was in fact understood

One of many 58 degree included in the descriptive investigation, 41 had been circumstances reports, you to definitely was a case show, thirteen have been retrospective cohort education, one or two had been potential cohort training, and something is actually a combination-sectional cohort study. The female NF1 clients having breast cancer came from 23 different nations, towards majority of her or him coming from the united states from America (38%), Uk (31%), and you may Japan (12%). Services of those instances is revealed for the Dining table 1.

Breast cancer stage at time of diagnosis was reported in 54 cases (27 cases of patients < 50 years of age and 27 cases of patients ?50 years of age)

Of the 286 cases identified, 181 reported the age of the patient. Mean age at breast cancer diagnosis was 49.3 years with a median age of 46 years and an interquartile range of 38.3 to 58.0 years. The majority of the patients were < 50 years of age with 53% < 50 years old, 28% between 35 and 44 years old and 15% < 35 years old. Age distribution of the incidence of breast cancer identified in these NF1 cases was evaluated based on their age at the time of diagnosis and revealed a peak age of diagnosis between the ages of 34 to 44 years. 2a).

Descriptive studies regarding breast cancer times stated. good Age shipping of chance away from cancer of the breast understood into the 181 NF1 hot or not-datingwebsite patients compared to the SEER databases said cancer of the breast years shipments regarding experience cases. b Shipping out of breast cancer phase from the time of diagnosis out-of cancer of the breast known in the 54 NF1 people. c Years shipment of your occurrence of cancer of the breast death identified inside the 76 NF1 people compared to the SEER database claimed breast disease many years shipping regarding deaths

This frequency out-of breast cancer times is compared to the SEER database to have advertised breast cancer years distribution off experience times, which displayed a highest period of diagnosis amongst the chronilogical age of 55 to 64 age regarding general populace (Fig

The type of breast cancer was reported in 110 cases; invasive ductal carcinoma (IDC) was the most commonly reported breast cancer subtype (75.5%). The other 176 breast cancer cases were identified as breast carcinoma. When analyzing all the female NF1 patients with breast cancer, the majority presented with stage I or II disease. However, when separated by age, women < 50 years of age presented with more advanced disease compared to those ?50 years of age (56% vs. 22% stage III-IV, respectively, p = 0.005; Fig. 2b).

Follow-up information was provided in 76 of the reported cases. Mean follow-up time was 44.7 months with a range of 1.9 to 204 months. Nearly half of the reported patients were dead at the time of last follow-up. Mean age at breast cancer death was 45.7 years with a median age of 48.5 years and an interquartile range of 41.3–59.7 years. The majority of the patients were < 50 years of age at time of breast cancer death with 64% < 50 years old, 38% between 35 and 44 years old and 10% < 35 years old. This incidence of breast cancer deaths was compared to the SEER database for reported breast cancer age distribution of deaths, demonstrating a peak age of death between the ages of 55 to 64 years in the general population (Fig. 2c). The relative survival of the female NF1 patients with breast cancer identified in this study was compared to the general population using the SEER database controlling for age and year at diagnosis for each patient (Fig. 3). The median survival for this entire NF1 breast cancer cohort was 5 years compared to the reported median breast cancer survival of over 20 years in the general population using the SEER database. When separated by age, the median survival of the female NF1 patients with breast cancer identified in this study was 5.58 years in those < 50 years of age and over 15 years in those ?50 years of age.